Week 1 college football is HERE, and the stakes are higher than ever! Are you ready to dive into the action with some killer betting insights? Our experts have crunched the numbers for Ohio State vs. Texas, LSU vs. Clemson, and more. Think you know who’s going to dominate?

The highly anticipated Week 1 of the 2025 college football season is officially underway, bringing with it a torrent of thrilling matchups and unparalleled opportunities for savvy bettors. Fans are not only treated to elite collegiate action but also a chance to capitalize on expert insights for their college football betting strategies, making every snap and touchdown a potential win.

DraftKings stands as the premier destination for enthusiasts looking to engage with this exciting slate of games, offering a robust platform designed to enhance the Week 1 CFB picks experience. With generous bonus bets available, it’s an opportune moment for both seasoned and new bettors to dive into the action with confidence and maximize their DraftKings predictions.

A monumental clash features No. 1 Texas against No. 3 Ohio State, a rematch of last season’s Cotton Bowl. This game is defined by stellar defenses, with Ohio State leading the nation in several key defensive metrics and Texas close behind. The SportsLine analysis for this marquee matchup notably projects the total score to stay Under 47.5 points, highlighting the expected defensive battle.

SportsLine’s proprietary computer model is the backbone of these insightful Week 1 CFB picks. Simulating every FBS game an astounding 10,000 times, the model boasts an impressive track record, generating a substantial betting profit of well over $2,000 for $100 players on its top-rated college spread football picks alone. Its consistent profitability makes it an invaluable resource for college football betting.

Another high-octane encounter pits No. 9 LSU against No. 4 Clemson, a game expected to feature explosive offenses. Clemson’s Cade Klubnik and LSU’s Garrett Nussmeier are set to lead their teams in what promises to be an offensive showcase. Based on thorough SportsLine analysis, the model forecasts a combined score of 64 points in this thrilling contest, indicating a potential shootout.

Beyond the headline games, Week 1 also presents intriguing matchups such as California versus Oregon State. These games, though perhaps less publicized, offer significant betting value, with Oregon State entering as a 1.5-point favorite. Such diverse options underscore the depth of college football betting opportunities available.

For those looking to amplify their returns, combining several Week 1 CFB picks into a parlay at DraftKings can yield substantial payouts. For instance, successfully parlaying three of the model’s top predictions could result in a payout of +617, turning a $100 risk into a $617 win and showcasing the lucrative nature of well-researched DraftKings predictions.

Accessing the comprehensive suite of against-the-spread, total, and money-line picks for every Week 1 CFB game from SportsLine’s consistently profitable model is crucial for informed college football betting. These meticulously generated predictions offer an edge in navigating the complexities of the opening week.

Furthermore, insights from legendary college football handicapper Bruce Marshall and SportsLine’s Emory Hunt, who holds a strong 45-32 record on his last 77 college football picks, provide additional layers of expert guidance. These diverse perspectives ensure bettors have a complete picture before finalizing their Week 1 CFB picks, ultimately enhancing their college football betting strategy.